Debris actually pelts the ISS all the time, and noticeable dents and cracks line the exteriors. But should something fully breach the station, cabin atmosphere will seep into the vacuum of space and alarms will go off. Pressure gauges will confirm to astronauts that the station has, almost certainly, been hit, and the speed of the seepages may indicate how much time the crew has to respond. According to one NASA estimate, a 0.6-centimeter-wide hole leaves 14 hours to plug the leak. A 20-centimeter hole leaves less than a minute.
But in the worst worst-case scenario, we don’t have any control. Instead, the station will crack through the atmosphere. Sure, many pieces will likely end up in the ocean, but some might hit people, possibly in a town or a city. The station could break apart across thousands of miles and multiple continents. This would be exceedingly hard to anticipate. As NASA puts it, “Calculating the probability of this penetration cascading into loss of deorbit capability has a very large range of variables, making predictions ineffective.”
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Even Benjamin Franklin's face on a piece of paper can feel like a mere proxy
与Vosoritide相比,Infigratinib作为FGFR酪氨酸激酶抑制剂,直接靶向致病根源——过度活跃的FGFR3,从源头上“释放刹车”,从而恢复软骨细胞正常功能。